Target related in silico analysis of Bergenin and tuberculosis management

Introduction and Aim: Tuberculosis (TB) is a global health concern, claiming two million lives every year. Although an oldest known human infectious disease, researcher falling short of giving out effective reliable vaccine or therapy. The current antimycobacterial drugs include Isoniazid, Ethambutol, Rifampicin Pyrazinemamide available in market, but most these are to have certain adverse effects. Hence there increase demand for natural products with anti-tuberculosis activity no limited side Indian traditional systems medicine plethora promising plants treatment tuberculosis, which Bergenin the well established extensively used compound. main aim this research was investigate role as agent help in-silico analysis protein interaction studies.
 Materials Methods: In present study 04 3-dimensional crystallized anti-tubercular drug target considered retrieved from PDB. Drug Rifampicin, Pyrazineamide phytochemical were retrieved, sketched geometrically optimized. Molecular docking carried understand binding mode its core interactions. ADMET properties calculated assessment toxicity. Protein-protein interactions enrichment biological process involved rpsA protein.
 Results: other than reported better energy similar pharmacophoric pattern compared all indigenous inhibitors. PPI network predicts plausible can be further targeted tuberculosis.
 Conclusion: results showed that competent existing if studied in-vitro in-vivo activity.